Growth Factors

Bone morphogenic protein

Bone morphogenic protein is an isolated protein that induces specific cells in our body to form new cartilage and bone. During surgery, the BMP is soaked onto and binds with a collagen sponge. The sponge is then designed to resorb, or disappear, over time. As the sponge dissolves, the bone morphogenic protein stimulates the cells to produce new bone. The BMP also goes away once it has completed its task of jump-starting the normal bone healing process.

Since there is no need to harvest bone from the patients’ hip for BMP, recipients were spared donor site pain. Complications from the graft harvest site are also eliminated with the use of bone morphogenic protein.

Dr. Fort would be happy to discuss all grafting options with you at the time of consultation.

Platelet Rich Fibrin

Platelet rich fibrin (PRF) is a by-product of blood (plasma) that is rich in platelets. Until now, its use has been confined to the hospital setting. This was due mainly to the cost of separating the platelets from the blood and a large amount of blood needed to produce a suitable quantity of platelets. New technology permits doctors to harvest and produce a sufficient quantity of platelets from only 55 ccs of blood, which is drawn from the patient while they are having outpatient surgery.

Why all the excitement about PRF?

PRF permits the body to take advantage of the normal healing pathways at a greatly accelerated rate. During the healing process, the body rushes many cells and cell-types to the wound in order to initiate the healing process. One of those cell types is platelets. Platelets perform many functions, including the formation of a blood clot and the release of growth factors (GF) into the wound. These growth factors; platelet-derived growth factors (PDGF), transforming growth factor beta (TGF), and insulin-like growth factor (ILGF), function to assist the body in repairing itself by stimulating stem cells to regenerate new tissue. The more growth factors released and sequestered into the wound, the more stem cells are stimulated to produce new tissue. Thus, PRF permits the body to heal faster and more efficiently.

A subfamily of TGF is bone morphogenic protein (BMP). BMP has been shown to induce the formation of new bone in research studies in both animals and humans. This is of great significance to the surgeon who places dental implants. By adding PRF, and BMP, to the implant site with bone substitute particles, the implant surgeon can now grow bone more predictably and faster than ever before.

PRF Has Many Clinical Applications

PRF can be used to aid bone grafting for dental implants. This includes onlay and inlay grafts, sinus lift procedures, ridge augmentation procedures, closure of cleft and/or lip, and palate defects. It can also assist in repair of bone defects created by removal of teeth, or small cysts and repair of fistulas between the sinus cavity and mouth.

PRF Also Has Many Advantages

  • Safety: PRF is a by-product of the patient’s own blood, therefore, disease transmission is not an issue.
  • Convenience: PRF can be generated in the doctor’s office while the patient is undergoing an outpatient surgical procedure such as the placement of dental implants.
  • Faster healing: The supersaturation of the wound with PRF, and thus growth factors, produces an increase of tissue synthesis and faster tissue regeneration.
  • Cost-effectiveness: Since PRF harvesting is done with only 55 ccs of blood in the doctor’s office, the patient need not incur the expense of the harvesting procedure in a hospital or at a blood bank.
  • Ease of use: PRF is easy to handle and actually improves the ease of application of bone substitute materials and bone grafting products by making them more gel-like.

Frequently Asked Questions About PRF

Is PRF safe? Yes. During the outpatient surgical procedure, a small amount of your own blood is drawn out via the IV. This blood is then placed in the PRF centrifuge machine and spun down. In less than 15 minutes, the PRF is formed and ready to use.

Should PRF be used in all bone-grafting cases? Not always. In some cases, there is no need for PRF. However, in the majority of cases, the application of PRF to the bone graft will increase the final amount of bone present, in addition to making the wound heal faster and more efficiently.

Will my insurance cover the costs? Unfortunately not. The cost of the PRF application is paid by the patient.

Can PRF be used alone to stimulate bone formation? No. PRF must be mixed with either the patient’s own bone, a bone substitute material such as demineralized freeze-dried bone, or a synthetic bone product, such as BIO-OSS.

Are there any contraindications to PRF? Very few. Obviously, patients with bleeding disorders or hematologic diseases do not qualify for this in-office procedure. Check with your surgeon and/or primary care physician to determine if PRF is right for you.

Get the best oral surgery services

For additional information about Platelet Rich Fibrin or to schedule an appointment with Oral Surgeon Dr. Fort, please contact us at St. Petersburg Oral Surgery & Dental Implants Phone Number 727-525-5455 or

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